Rodenstein D, Stănescu D C
Br J Dis Chest. 1982 Oct;76(4):365-73. doi: 10.1016/0007-0971(82)90072-9.
Four hundred micrograms of fenoterol aerosol were administered to 10 healthy subjects and nine asthmatic patients. Fenoterol was either inhaled or sprayed into the mouth carefully avoiding inhalation. Forced vital capacity (FVC), forced expiratory volume in one second (FEV1.0), maximal expiratory flow rates (MEFR), specific airways conductance (sGaw), total lung capacity (TLC), residual volume (RV), and heart rate (HR) were measured before and up to one hour after fenoterol administration. FVC, FEV1.0, MEFR and sGaw increased significantly after inhalation of fenoterol in both asthmatic patients and healthy subjects. The increase was significantly greater in the asthmatic group. After buccal administration of fenoterol FVC, FEV1.0 and sGaw increased significantly in both asthmatic patients and healthy subjects, and there was no significant difference between the two groups. Increased heart rate and side effects were observed only in healthy subjects and only after inhalation. Buccal administration of fenoterol to both asthmatic patients and healthy subjects induced a clearcut bronchodilation (though less than that produced by inhalation), probably by absorption of the drug through the oral mucosa.
给10名健康受试者和9名哮喘患者使用了400微克非诺特罗气雾剂。非诺特罗要么吸入，要么小心地喷入口腔，避免吸入。在给予非诺特罗之前及之后长达1小时内，测量用力肺活量（FVC）、一秒用力呼气量（FEV1.0）、最大呼气流量（MEFR）、比气道传导率（sGaw）、肺总量（TLC）、残气量（RV）和心率（HR）。哮喘患者和健康受试者吸入非诺特罗后，FVC、FEV1.0、MEFR和sGaw均显著增加。哮喘组的增加幅度明显更大。哮喘患者和健康受试者经口腔给予非诺特罗后，FVC、FEV1.0和sGaw均显著增加，两组之间无显著差异。仅在健康受试者吸入后观察到心率增加和副作用。哮喘患者和健康受试者经口腔给予非诺特罗均引起明显的支气管扩张（尽管小于吸入产生的扩张），可能是药物通过口腔黏膜吸收所致。
