Williams J T, Zieglgänsberger W
Brain Res. 1982 Dec 16;253(1-2):125-31. doi: 10.1016/0006-8993(82)90679-5.
Capsaicin applied to the soma of fast and slow conducting primary afferent fibers had a depolarizing action associated with an increase in membrane conductance. The depolarizing effect desensitized rapidly and was only partially reversible in slow conducting fibers. Capsaicin application to the entry zone of the appropriate dorsal rootlets led to strong excitation of dorsal horn neurons receiving multimodal input. After acute capsaicin treatment the response to noxious heat was attenuated or totally absent, while other noxious stimuli were still effective. The present data suggest that capsaicin exerts its specific degenerative action by a long-lasting depolarizing action on small-calibre fibers.
将辣椒素应用于快速和慢速传导的初级传入纤维的胞体，会产生与膜电导增加相关的去极化作用。这种去极化效应迅速脱敏，并且在慢速传导纤维中仅部分可逆。将辣椒素应用于相应背根小束的进入区域，会导致接受多模式输入的背角神经元强烈兴奋。急性辣椒素处理后，对有害热的反应减弱或完全消失，而其他有害刺激仍然有效。目前的数据表明，辣椒素通过对小口径纤维的持久去极化作用发挥其特定的退行性作用。
