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[大鼠急性肠缺血早期的生物学紊乱。血磷和血清碱性磷酸酶的测定]

[Early biological disorders in acute intestinal ischemia in the rat. Determination of blood phosphorus and serum alkaline phosphatase].

作者信息

Grise P, Tenière P, Hue G, Metayer J

出版信息

J Chir (Paris). 1982 Nov;119(11):655-8.

PMID:7153264
Abstract

Though difficult, early diagnosis of acute intestinal ischemia is essential in order to improve the prognosis of this major affection. The possibility that early modifications in biological parameters could provide such data was explored. Serum alkaline phosphatase levels were unaltered, whereas blood phosphorus concentrations were increased during AII of arterial or venous origin in the rat. The latter test therefore provides an early specific indication of the diagnosis, the mechanism involved being liberation of phosphate ions from the intestine, enhanced by a functional renal insufficiency.

摘要

尽管困难重重,但急性肠缺血的早期诊断对于改善这种主要疾病的预后至关重要。人们探索了生物参数的早期改变能否提供此类数据。血清碱性磷酸酶水平未发生变化,而在大鼠动脉或静脉源性急性肠缺血期间,血磷浓度升高。因此,后一项检测为诊断提供了早期特异性指标,其涉及的机制是由于功能性肾功能不全导致磷酸根离子从肠道释放增加。

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