Sigdell J E
Int J Artif Organs. 1982 Nov;5(6):361-72.
The clearance of a dialyzer is calculated under the most general conditions, allowing not only for a mixed diffusive and convective mass transfer, but also for a variation along the membrane of the local ultrafiltration, the membrane permeability and the sieving coefficient. The study is then carried on for the case in which these are all constant, to reach a relatively simple expression for the influence of a low ultrafiltration rate on the clearance. In this study, the permeabilities of the boundary layers on both sides are treated as included in the (equivalent) membrane. In an appendix, the stacking of membranes is studied, giving a general law for the calculation of overall permeabilities of a stack of individual membranes, regarded as one (equivalent) membrane (such as a physical membrane with two boundary layers). Permeability data for boundary layers are quoted from earlier works. In other appendices, the variation of the local ultrafiltration along the dialysis path is studied, as well as its effect on the effective permeability of the membrane.
透析器的清除率是在最一般的条件下计算的，不仅考虑了扩散和对流混合传质，还考虑了沿膜的局部超滤、膜通透性和筛分系数的变化。然后针对这些参数均为常数的情况进行研究，以得出超滤率较低时对清除率影响的相对简单的表达式。在本研究中，两侧边界层的通透性被视为包含在（等效）膜中。在附录中，研究了膜的堆叠情况，给出了一个计算单个膜堆叠（视为一个（等效）膜，如具有两个边界层的物理膜）总通透性的一般规律。边界层的通透性数据引自早期研究。在其他附录中，研究了沿透析路径的局部超滤变化及其对膜有效通透性的影响。
