钙拮抗剂，尤其是硝苯地平，对变异型心绞痛、静息型心绞痛和不稳定型心绞痛的作用。

Effects of calcium antagonists, especially nifedipine, on variant angina, resting angina, and unstable angina.

作者信息

Kishida H, Otsu F, Kusama Y, Takayama M, Hayakawa H, Kimura E

出版信息

Jpn Heart J. 1982 Nov;23(6):871-81. doi: 10.1536/ihj.23.871.

DOI:10.1536/ihj.23.871

Abstract

The effects of drugs were evaluated in 47 cases with variant angina (VA), 19 with resting angina showing ST depression (RA), and 84 with unstable angina (UA). In VA patients, calcium antagonists were effective in 87.1% of the cases, while other drugs were effective in 56.3%. The difference was statistically significant. In RA patients, calcium antagonists were effective in 80.0% of the cases and other drugs in 44.4%. Nifedipine was effective in all 5 cases with coronary stenosis of more than 75.0%. All cases of RA had multiple vessel disease and nifedipine was effective in 80.0% of the patients. Nifedipine was effective in 83.3% of VA cases showing ST elevation during an exercise test, and was particularly effective in all patients having attacks only at rest. The effects of nifedipine were confirmed in 83.3% of UA cases. These results indicate that calcium antagonists are effective in VA, RA, and UA.

摘要

对47例变异型心绞痛（VA）患者、19例静息性心绞痛伴ST段压低（RA）患者和84例不稳定型心绞痛（UA）患者进行了药物疗效评估。在VA患者中，钙拮抗剂在87.1%的病例中有效，而其他药物的有效率为56.3%。差异具有统计学意义。在RA患者中，钙拮抗剂在80.0%的病例中有效，其他药物的有效率为44.4%。硝苯地平对所有5例冠状动脉狭窄超过75.0%的病例均有效。所有RA病例均有多支血管病变，硝苯地平在80.0%的患者中有效。硝苯地平在运动试验中出现ST段抬高的VA病例中有效率为83.3%，对所有仅在静息时发作的患者尤其有效。硝苯地平在83.3%的UA病例中疗效得到证实。这些结果表明，钙拮抗剂对VA、RA和UA均有效。