Padmaja G, Chempakam B, Kurup P A
Acta Diabetol Lat. 1978 Jan-Apr;15(1-2):16-23. doi: 10.1007/BF02581003.
The effect of insulin on the concentration of different glycosaminoglycan (CG) fractions was different in different segments of aorta. Chondroitin sulphate A and heparin were increased in the aortic arch, thoracic and abdominal aorta, while chondroitin sulphate B and C were increased only in the aortic arch and abdominal aorta. Heparin sulphate and hyalutonic acid were increased only in the abdominal aorta. In the liver, significant increases occurred in all GG fractions. All enzymes studied which are involved in the biosynthesis of GG precursors, i.e. glucosaminphosphate isomerase, UDP glucose dehydrogenase and glucose-1-phosphate uridylyltransferase, were increased in the animals of the insulin group, while all enzymes involved in the degradation of GG, i.e. hyalurono glucosidase, beta-glucosaminidase, arylsulphatase, and cathepsin D, were decreased. Concentration of hepatic PAPS, activity of the sulphate-activiting system and sulphotransferase increased on administration of insulin.
胰岛素对主动脉不同节段中不同糖胺聚糖（CG）组分浓度的影响有所不同。硫酸软骨素A和肝素在主动脉弓、胸主动脉和腹主动脉中增加，而硫酸软骨素B和C仅在主动脉弓和腹主动脉中增加。硫酸乙酰肝素和透明质酸仅在腹主动脉中增加。在肝脏中，所有CG组分均显著增加。在胰岛素组动物中，所有参与GG前体生物合成的研究酶，即氨基葡萄糖磷酸异构酶、UDP葡萄糖脱氢酶和葡萄糖-1-磷酸尿苷转移酶均增加，而所有参与GG降解的酶，即透明质酸葡萄糖苷酶、β-氨基葡萄糖苷酶、芳基硫酸酯酶和组织蛋白酶D均减少。给予胰岛素后，肝脏中PAPS的浓度、硫酸盐激活系统的活性和磺基转移酶均增加。
