Thomsen M B, Bengtsson M, Lassvik C, Lewis D H, Elfström J
Acta Chir Scand. 1982;148(8):657-61.
The effect of intravenous regional sympathetic blockade with guanethidine on total forearm blood flow and on muscle and skin blood flow in the forearm was studied in healthy humans, using venous occlusion plethysmography, 133Xe-clearance technique and skin temperature recordings. The total blood flow tripled in response to the blockade and the rise persisted for 2-3 days. The increase in blood flow was confined to the skin, with no demonstrable steal effect on muscle blood flow. The observations imply that this type of sympathetic blockade may be of therapeutic value in some vascular disorders of the hand, and as supportive treatment in vascular surgery on the extremities.
采用静脉阻断体积描记法、¹³³氙清除技术和皮肤温度记录法，在健康人体中研究了胍乙啶静脉局部交感神经阻滞对前臂总血流量以及前臂肌肉和皮肤血流量的影响。阻断后总血流量增加了两倍，且这种增加持续了2至3天。血流量的增加仅限于皮肤，对肌肉血流量没有明显的窃血效应。这些观察结果表明，这种类型的交感神经阻滞在手部某些血管疾病中可能具有治疗价值，并且可作为四肢血管手术的辅助治疗。
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