Tendler D S, Fashchevskaia I A
Probl Endokrinol (Mosk). 1977 Mar-Apr;23(2):94-9.
A study was made of the action of various doses of thyroidin in its prolonged administration to guinea pigs on the functional and morphological changes of the thyroid gland and the adenohypophysis. A high sensitivity of guinea pigs to the excess of thyroid hormone in comparison with such in dogs was shown. Already with the less thyroidin doses guinea pigs displayed an increased oxygen consumption under conditions of the basic metabolism, a marked increase of the content of protein-bound iodine in the blood serum and of the corticosteroid urinary excretion. There were revealed no significant differences in the thyroidin action depending on the method of its administration, i.e. in case of a gradual increase of the doses or in the administration of high doses from the very beginning. The presence of significant individual differences in guinea pigs in the resistance to the excess of the thyroid hormones was demonstrated.
对豚鼠长期给予不同剂量甲状腺素，研究其对甲状腺和腺垂体功能及形态变化的作用。结果表明，与犬相比，豚鼠对过量甲状腺激素具有较高的敏感性。给予较低剂量甲状腺素时，豚鼠在基础代谢条件下耗氧量增加，血清中蛋白结合碘含量显著升高，尿中皮质类固醇排泄量明显增加。研究发现，甲状腺素的作用方式（即剂量逐渐增加或从一开始就给予高剂量）对其作用效果无显著差异。研究还证实，豚鼠对过量甲状腺激素的耐受性存在显著个体差异。
