Kunschner A, Kanbour A I, David B
Am J Obstet Gynecol. 1978 Nov 15;132(6):599-606. doi: 10.1016/0002-9378(78)90850-5.
Fifty-eight cases of early vulvar neoplasia were reviewed from the Tumor Registry at Magee-Womens Hospital, between 1947 and 1976. Twenty-three cases were carcinoma in situ; 16 were microinvasive, and 19 were occult carcinoma. All of the cases were treated surgically. The modality of surgical treatment varied from local excision to radical vulvectomy with inguinal lymph node dissection. Regardless of the surgical therapy, none of the patients died of the vulvar malignancy. It is recommended, as part of routine gynecologic surveillance, that more critical attention be given to examination for early epithelial neoplastic lesions of the vulva. This can be accomplished by simple inspection and the use of special diagnostic aids. Biopsy specimens should be reviewed histologically for depth of invasion and the treatment individualized to the patient with considerations for conservatism, especially in younger women.
回顾了1947年至1976年间 Magee 妇女医院肿瘤登记处的58例早期外阴肿瘤病例。其中23例为原位癌；16例为微浸润癌，19例为隐匿性癌。所有病例均接受了手术治疗。手术治疗方式从局部切除到根治性外阴切除术加腹股沟淋巴结清扫术不等。无论采用何种手术治疗，均无患者死于外阴恶性肿瘤。建议作为常规妇科检查的一部分，更密切地关注对外阴早期上皮性肿瘤病变的检查。这可以通过简单的检查和使用特殊诊断辅助手段来实现。活检标本应进行组织学检查以确定浸润深度，并根据患者情况进行个体化治疗，尤其对于年轻女性要考虑保守治疗。
