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Some new 1-(2'-methyl-6'-methoxy-quinoline-4'-yl amino)-2-methyl-4-arylidene-imidazolin-5-ones as anticonvulsant and analgesic agents.

作者信息

Lata A, Satsangi R K, Srivastava V K, Bhargava K P

出版信息

Pol J Pharmacol Pharm. 1982;34(4):217-22.

PMID:7182842
Abstract

Seventeen new 1-(2'-methyl-6'-methoxyquinoline-4'-yl-amino)-2-methyl-4-arylideneimidazol-5-ones have been synthesized by the condensation between the respective azlactones (prepared by the well known Erlenmeyer azlactone synthesis) and 2-methyl-4 hydrazino-6-methoxy-quinolines. The compounds have been found to possess anticonvulsant activity against maximal electroshock seizures and chemoshock induced seizures and the analgesic activity. Some qualitative structure activity relationship has been established.

摘要

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