禁食对HI-6急性毒性及其对梭曼中毒小鼠疗效的影响。
Effect of fasting on the acute toxicity of HI-6 and its efficacy in soman poisoned mice.
作者信息
Clement J G
出版信息
Fundam Appl Toxicol. 1982 Mar-Apr;2(2):88-9. doi: 10.1016/s0272-0590(82)80120-6.
PMID:7185607
Abstract
In rodents HI-6 is a very effective antidote of soman poisoning. After fasting, the IP LD50 value of HI-6 decreased from 660 mg/kg to 550 mg/kg. Fasting had no significant effect on the IV LD50 of HI-6. In fasted animals the ED50 for HI-6 (plus atropine) in soman toxicity decreased from 47.5 mg/kg to 14.8 mg/kg. Investigators should be aware of the nutritional status of the animals when comparing data between various laboratories.
摘要
在啮齿动物中，HI-6是梭曼中毒的一种非常有效的解毒剂。禁食后，HI-6的腹腔注射半数致死剂量（IP LD50）值从660毫克/千克降至550毫克/千克。禁食对HI-6的静脉注射半数致死剂量（IV LD50）没有显著影响。在禁食动物中，HI-6（加阿托品）对梭曼中毒的半数有效剂量（ED50）从47.5毫克/千克降至14.8毫克/千克。在比较不同实验室的数据时，研究人员应注意动物的营养状况。
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