Rothenberger K, Pensel J, Hofstetter A, Keiditsch E, Stern J
Urologe A. 1981 Sep;20 Suppl:310-4.
Therapy of urinary bladder tumors with the aid of the Neodymium-YAG-laser is improved by two following demands. A homogeneous, deep necrosis must be obtained for the tumor cells to be devitalised completely, and neighbouring organs must be protected adequately. Both depth and shape of the necrosis were determined on liver tissue at different conditions, e.g. laser application with air, water and various time/power ratios. Measurements of temperature profiles at the bladder back wall reveal that the parameters necessary for sufficient transmural destruction of bladder tumors do not affect neighbouring organs. In clinical application it is not necessary to control temperatures occurring at the bladder wall during irradiation by means of temperature probes. It is sufficient to adjust the dosis of laser on the basis of superficial, visual discoloration. Carbonisation should be avoided by all means. Comparable effects were obtained by clinical application of data obtained during animal experimentation.
借助钕钇铝石榴石激光治疗膀胱肿瘤可通过以下两个要求得到改进。必须实现均匀的深度坏死，以使肿瘤细胞完全失去活力，并且必须充分保护邻近器官。在不同条件下，例如在空气、水以及各种时间/功率比的情况下对肝脏组织进行激光照射，以此确定坏死的深度和形状。对膀胱后壁温度分布的测量表明，实现膀胱肿瘤充分透壁破坏所需的参数不会影响邻近器官。在临床应用中，无需通过温度探头控制照射期间膀胱壁出现的温度。根据表面的视觉变色来调整激光剂量就足够了。应千方百计避免碳化。通过临床应用动物实验期间获得的数据也取得了类似的效果。
