Annegers J F, Hauser W A, Anderson V E, Kurland L T
Neurology. 1982 Feb;32(2):174-9. doi: 10.1212/wnl.32.2.174.
The risk of seizure disorders in relatives of patients with childhood-onset epilepsy was evaluated by a cohort study of the other descendants of parents of probands with epilepsy. The probands comprised 196 cases of idiopathic epilepsy and 60 individuals with isolated idiopathic seizures diagnosed among residents of Rochester, Minnesota, from 1935 to 1974. The risk of epilepsy through age 20 among the siblings and children of probands was 4.1%, three times the rate in the general Rochester population. The risk of any type of seizure (including isolated seizures, febrile convulsions, or seizures due to an acute cerebral insult) through age 20 was 11% in siblings and 13.1% in children of probands. The risks of seizure disorders among the nieces and nephews of probands were not greater than the general population rates.
通过对癫痫先证者父母的其他后代进行队列研究,评估了儿童期癫痫患者亲属患癫痫症的风险。先证者包括196例特发性癫痫病例以及1935年至1974年在明尼苏达州罗切斯特市居民中诊断出的60例孤立性特发性发作个体。先证者的兄弟姐妹和子女在20岁之前患癫痫的风险为4.1%,是罗切斯特市普通人群发病率的三倍。先证者的兄弟姐妹在20岁之前出现任何类型发作(包括孤立性发作、热性惊厥或急性脑损伤所致发作)的风险为11%,子女为13.1%。先证者的侄子侄女患癫痫症的风险不高于普通人群发病率。