Slatkin M
Genetics. 1980 Jun;95(2):503-24. doi: 10.1093/genetics/95.2.503.
The results are presented from a simulation study of the spatial distribution of mutant alleles in a subdivided population. Statistical measures of the spatial pattern are defined in such a way that the same quantities could be measured in a geographic survey of allele frequencies in natural populations. Two types of quantities are discussed in this paper: (1) the occupancy distribution provides information on the presence or absence of the mutant in different numbers of demes; and (2) the conditional frequency distribution provides information about the extent of local differentiation when the mutant is present in different numbers of demes. Properties of these distributions are found for different types of natural selection acting on the mutant. Some results are presented for the same statistical measures based on samples of individuals from a fraction of the total number of demes. The simulation results for intermediate levels of the migration rates are compared with analytic results obtained on the limits of high and low migration rates. The main conclusion is that these measures of the spatial distribution of mutants in a subdivided population have simple properties that could provide a new perspective on data from natural populations.
本文展示了对一个细分种群中突变等位基因空间分布的模拟研究结果。空间模式的统计度量以这样一种方式定义，即相同的量可以在自然种群等位基因频率的地理调查中进行测量。本文讨论了两种类型的量：（1）占有率分布提供了关于突变体在不同数量群落中存在或不存在的信息；（2）条件频率分布提供了关于当突变体存在于不同数量群落中时局部分化程度的信息。针对作用于突变体的不同类型自然选择，发现了这些分布的性质。基于从总数一部分群落中抽取的个体样本，给出了相同统计度量的一些结果。将中等迁移率水平的模拟结果与在高迁移率和低迁移率极限情况下获得的分析结果进行了比较。主要结论是，这些细分种群中突变体空间分布的度量具有简单的性质，可为来自自然种群的数据提供新的视角。
