溴隐亭在体外刺激小鼠睾丸产生睾酮。
Bromocriptine stimulates testosterone production by mouse testes in vitro.
作者信息
Bartke A, Lackritz R M
出版信息
Fertil Steril. 1981 Apr;35(4):472-6.
The production of testosterone (T) by decapsulated mouse testes in vitro was significantly stimulated by 2-Br-alpha-ergocriptine (bromocriptine) at concentrations ranging from 1 ng/ml to 5 microgram/ml. In the presence of a low dose of human chorionic gonadotropin (hCG), bromocriptine produced a further increase in T production, whereas in the presence of a high concentration of hCG it was ineffective. It is suggested that a direct stimulatory effect of bromocriptine on testicular steroidogenesis may contribute to its therapeutic effects in hyperprolactinemic men.
在体外，去包膜的小鼠睾丸产生睾酮（T）的过程在浓度范围为1纳克/毫升至5微克/毫升的2-溴-α-麦角隐亭（溴隐亭）作用下受到显著刺激。在低剂量人绒毛膜促性腺激素（hCG）存在的情况下，溴隐亭使T的产生进一步增加，而在高浓度hCG存在时则无效。有人提出，溴隐亭对睾丸类固醇生成的直接刺激作用可能有助于其对高催乳素血症男性的治疗效果。
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