Renvall S, Niinikoski J
Acta Chir Scand. 1980;146(7):493-9.
Oxygen consumption by various tissues and peritoneal fluid cells was investigated in silica-induced adhesion disease and fecal peritonitis in rats. Intraperitoneally injected colloidal silica produced chemical peritonitis with a typical acute inflammatory reaction of peritoneal fluid cells showing marked phagocytosis by macrophages. The quantity of cells in the peritoneal fluid as indicated by the content of DNA achieved its maximum within 2-4 days. At the peritoneal surface, abundant proliferative reaction occurred already 2-3 days after silica injection, followed later by aggregation of collagen fibres and finally by peritoneal hyalinization. Oxygen utilization by various tissues--such as liver, kidney, heart, skeletal muscle, lung, spleen and intestine--increased by 20-80% above normal during the first 2 days after silica injection and returned to the original level within the following 5 days. In comparison, fecal peritonitis resulting in death of the animals within 12-36 hours caused a transient fall in tissue oxygen consumption at 12 hours. In the peritoneal fluid of rats injected with silica, oxygen utilization per DNA decreased by more than 50% from the original level during the first 24 hours and remained approximately 20% below normal thereafter. It is concluded that at the early phase of silica-induced peritonitis, oxygen consumption increases both locally in the abdomen and in distant tissues.
在大鼠二氧化硅诱导的粘连性疾病和粪便性腹膜炎中，研究了各种组织和腹膜液细胞的氧消耗情况。腹腔注射胶体二氧化硅可引发化学性腹膜炎，腹膜液细胞出现典型的急性炎症反应，巨噬细胞表现出明显的吞噬作用。以DNA含量表示的腹膜液中细胞数量在2 - 4天内达到最大值。在腹膜表面，注射二氧化硅后2 - 3天就已出现丰富的增殖反应，随后是胶原纤维聚集，最终导致腹膜透明化。在注射二氧化硅后的头2天内，肝脏、肾脏、心脏、骨骼肌、肺、脾脏和肠道等各种组织的氧利用率比正常水平提高了20 - 80%，并在接下来的5天内恢复到原始水平。相比之下，导致动物在12 - 36小时内死亡的粪便性腹膜炎在12小时时会导致组织氧消耗短暂下降。在注射二氧化硅的大鼠腹膜液中，每DNA的氧利用率在最初24小时内比原始水平降低了50%以上，此后仍比正常水平低约20%。得出的结论是，在二氧化硅诱导的腹膜炎早期，腹部局部和远处组织的氧消耗都会增加。
