Colliard M, Duprey J, Baglin A, Domart M, Felsenheld P
Ann Med Interne (Paris). 1980;131(7):401-5.
Pathophysiology of diabetic microangiopathy is unclear, but hyperglycemia is admitted as an important factor. In three patients having microangiopathy with lesions very similar to those of diabetes (one nodular glomerulosclerosis, two retinopathies), glucose tolerance was found normal. Such cases, already reported, but rather rare, raise the question of the validity of tests currently used in the diagnosis of diabetes, of the importance of hyperglycemia compared to others factors (specially genetic) in the occurrence of microangiopathy, and of the specificity of these lesions.
糖尿病微血管病变的病理生理学尚不清楚,但高血糖被认为是一个重要因素。在三名患有微血管病变且病变与糖尿病病变非常相似的患者中(一名为结节性肾小球硬化,两名患有视网膜病变),发现其糖耐量正常。此类病例虽已被报道,但相当罕见,这引发了当前用于诊断糖尿病的检测方法的有效性问题、高血糖相对于其他因素(特别是遗传因素)在微血管病变发生中的重要性问题以及这些病变的特异性问题。