Piercey M F, Schroeder L A
Arch Int Pharmacodyn Ther. 1980 Dec;248(2):294-304.
A DC ramp voltage was used to stimulate rabbit tooth pulps. Thresholds to elicit chewing movements were extremely stable in the absence of drug treatment. Using cumulative dosing of analgesic drugs, potency and efficacy measurements could be readily obtained. Narcotic analgesics were the most effective analgesics on this test, followed by two centrally acting non-narcotics (nefopam and baclofen). Antipyretic/anti-inflammatory analgesics and centrally acting non-analgesic drugs elevated thresholds by lesser amounts or were inactive. It is concluded that the rabbit tooth pulp assay is suitable for the qualitative and quantitative determination of analgesic activity.
使用直流斜坡电压刺激兔牙髓。在未进行药物治疗的情况下，引发咀嚼运动的阈值极其稳定。通过累积给予镇痛药，可以很容易地获得效能和效价测量值。在该试验中，麻醉性镇痛药是最有效的镇痛药，其次是两种中枢作用的非麻醉药（奈福泮和巴氯芬）。解热/抗炎镇痛药和中枢作用的非镇痛药提高阈值的幅度较小或无活性。结论是兔牙髓试验适用于镇痛活性的定性和定量测定。
