Fujimoto S, Sasa M, Takaori S
Brain Res Bull. 1981 Mar;6(3):267-74. doi: 10.1016/s0361-9230(81)80057-3.
Electrophysiological studies were performed to determine if the locus coeruleus (LC) plays a role in regulating activity of caudate nucleus (CN) neurons. Cats were anesthetized with alpha-chloralose and when conditioning stimuli were applied to the LC, preceding the test stimulus, there was a significant inhibition of spike generation in 33 out of 93 CN neurons transsynaptically activated by test stimulus to the pars compacta of the substantia nigra (SN). An inhibition of spike generation with LC conditioning stimulation and iontophoretic application of noradrenaline was obtained in 9 out of the same 23 CN neurons and 8 neurons remained unaffected with either treatment. In contrast to these neurons, LC conditioning stimulation did not affect the spontaneous firing and spike generation of CN neurons antidromically excited by SN stimulation. Spike firing of CN neurons transsynaptically activated by motor cortex stimulation remained unaffected with LC conditioning stimulation. These results suggest that noradrenaline derived from the LC produced an inhibition of spike generation in about one-third of CN neurons tested and transsynaptically activated by SN stimulation.
进行电生理研究以确定蓝斑（LC）是否在调节尾状核（CN）神经元的活动中发挥作用。用α-氯醛糖麻醉猫，当在测试刺激之前对LC施加条件刺激时，在93个经黑质致密部（SN）测试刺激经突触激活的CN神经元中，有33个的锋电位产生受到显著抑制。在相同的23个CN神经元中的9个中，通过LC条件刺激和去甲肾上腺素的离子电渗法应用获得了锋电位产生的抑制，并且8个神经元在两种处理下均未受影响。与这些神经元相反，LC条件刺激不影响经SN刺激逆向兴奋的CN神经元的自发放电和锋电位产生。由运动皮层刺激经突触激活的CN神经元的锋电位发放不受LC条件刺激的影响。这些结果表明，源自LC的去甲肾上腺素在约三分之一经测试且经SN刺激经突触激活的CN神经元中产生了锋电位产生的抑制。
