慢性HBsAg携带者中抗DNA、抗HBc与放射免疫分析法检测的HBeAg和抗HBe的相关性。

Anti-DNA, anti-HBc correlations with RIA-detected HBeAg and anti-HBe in chronic HBsAg carriers.

作者信息

Villarejos V M, Andersen-Visoná K, Serra J, Frösner G G, Deinhardt F

出版信息

J Med Virol. 1980;5(4):265-71. doi: 10.1002/1096-9071(1980)5:4<265::aid-jmv1890050402>3.0.co;2-n.

DOI:10.1002/1096-9071(1980)5:4<265::aid-jmv1890050402>3.0.co;2-n

Abstract

The interrelations of 1) antibody to hepatitis B core antigen (HBcAg)--anti-HBc; 2) single-stranded DNA-binding antibodies (anti-DNA); and 3) the e-antigen/antibody system--hepatitis B e antigen (HBeAg) and antibody (anti-HBe), were studied in 150 hepatitis B surface antigen (HBsAg) carriers, in 43 of whom diagnostic liver biopsies had been performed. There was a good correlation between titers of anti-HBc and anti-DNA, regarded as indicators of viral and pathological activity, respectively, as well as between levels of these two antibodies and the presence of HBeAg or anti-HBE as detected by radio-immune assay (RIA). In general, HBeAg-positive carriers showed high anti-HBc and high anti-DNA titers, while the carriers positive for anti-HBe had low titers of both. These findings were in accord with the histopathological results. The three serologic parameters, anti-HBc, anti-DNA, and e-antigen/antibody, should together prove useful for the evaluation of the clinical status of chronic HBsAg carriers.

摘要

对150名乙型肝炎表面抗原（HBsAg）携带者研究了以下三者的相互关系：1）乙型肝炎核心抗原（HBcAg）抗体——抗-HBc；2）单链DNA结合抗体（抗-DNA）；3）e抗原/抗体系统——乙型肝炎e抗原（HBeAg）和抗体（抗-HBe）。其中43人进行了诊断性肝活检。抗-HBc和抗-DNA的滴度之间具有良好的相关性，分别被视为病毒活性和病理活性的指标，并且这两种抗体的水平与放射免疫测定（RIA）检测到的HBeAg或抗-HBe的存在之间也具有良好的相关性。一般来说，HBeAg阳性携带者显示出高抗-HBc和高抗-DNA滴度，而抗-HBe阳性的携带者两者滴度均低。这些发现与组织病理学结果一致。抗-HBc、抗-DNA和e抗原/抗体这三个血清学参数共同应可用于评估慢性HBsAg携带者的临床状态。