嗜银肠嗜铬样细胞胃类癌

Gastric carcinoids of argyrophil ECL cells.

作者信息

Capella C, Polak J M, Timson C M, Frigerio B, Solcia E

出版信息

Ultrastruct Pathol. 1980 Jul-Sep;1(3):411-8. doi: 10.3109/01913128009141444.

DOI:10.3109/01913128009141444

Abstract

Histochemical and ultrastructural studies were carried out in four gastric carcinoids, two of which were associated with atrophic gastritis and pernicious anemia. All tumors showed intense argyrophilia and vesicular granules resembling those of endocrine enterochromaffinlike (ECL) cells in normal human gastric mucosa. Tumor cells were found to be unreactive to all the 18 available antiserums to gut hormones, including gastrin, somatostatin, glucagon, and pancreatic polypeptides. The tumors were interpreted as ECL cell argyrophil carcinoids with the various degrees of differentiation and atypia.

摘要

对4例胃类癌进行了组织化学和超微结构研究，其中2例与萎缩性胃炎和恶性贫血相关。所有肿瘤均显示强嗜银性，且有类似于正常人胃黏膜内分泌肠嗜铬样（ECL）细胞的泡状颗粒。发现肿瘤细胞对所有18种现有的针对胃肠激素的抗血清均无反应，这些胃肠激素包括胃泌素、生长抑素、胰高血糖素和胰多肽。这些肿瘤被解释为具有不同程度分化和异型性的ECL细胞嗜银性类癌。