Trzebski A, Raczkowska M, Kubin L
Acta Neurobiol Exp (Wars). 1980;40(5):807-20.
Carotid baroreceptors were stimulated in 40 healthy volunteers by a rapid increase of the carotid transmural pressure due to subatmospheric pressure applied to a tight neck chamber (neck suction). Heart rate, arterial blood pressure and respiratory response were recorded. Reflex vagal inhibition of the sinus node preceded a blood pressure fall. Cardiac response adapted in a few seconds during prolonged baroreceptor stimulation, whereas reflex hypotension was maintained over the whole stimulation period applied up to 30 s. Augmented inspiratory movements were observed during neck suction. Short-lasting baroreceptor stimuli produced much less cardiac inhibition if applied during the early inspiratory than during the expiratory phase. On the peak and on the plateau of the voluntarily sustained deep inspirations, a spontaneous sinus bradycardia and a facilitation of the baroreceptor-cardiac reflex appeared. Voluntarily delayed expiration following deep and sustained inspiration coincided with cardioacceleration and baroreflex inbibition. Thus voluntarily Imposed, breathing patterns may reverse both respiratory sinus arrhythmia and cyclical modulation of the baroreflex responsiveness over the respiratory cycle.
通过对40名健康志愿者颈部施加低于大气压的压力（颈部抽吸），使颈动脉跨壁压迅速升高，从而刺激颈动脉压力感受器。记录心率、动脉血压和呼吸反应。血压下降之前，窦房结出现反射性迷走神经抑制。在长时间压力感受器刺激过程中，心脏反应在几秒钟内就会适应，而反射性低血压在长达30秒的整个刺激期内持续存在。颈部抽吸期间观察到吸气运动增强。如果在吸气早期施加短暂的压力感受器刺激，其产生的心脏抑制作用比在呼气期施加时要小得多。在主动维持的深呼吸的峰值和平台期，出现自发性窦性心动过缓和压力感受器 - 心脏反射的易化。在深而持续的吸气后主动延迟呼气与心动加速和压力反射抑制同时出现。因此，主动施加的呼吸模式可能会逆转呼吸性窦性心律失常以及压力反射反应性在呼吸周期中的周期性调节。
