Filice G A, Remington J S
Br J Exp Pathol. 1981 Apr;62(2):131-5.
Benzopyrones have been shown to affect several functions of macrophages. We examined the effects of two benzopyrones, coumarin and warfarin, on the capacity of mouse macrophages to inhibit microorganisms and tumour target cells. Mice were treated with daily i.v. doses of either drug. Then the mice were challenged with lethal doses of Toxoplasma gondii or peritoneal macrophages from these mice were challenged in vitro with T. gondii or tumour target cells Survival of coumarin or warfarin-treated mice challenged with T. gondii was similar to that of control mice. Multiplication of T gondii and growth of tumour target cells were similar in preparations of macrophages from coumarin-treated, warfarin-treated, or control mice and were inhibited in preparations of activated macrophages from Corynebacterium parvum-treated mice that served as positive controls. Under our experimental conditions, benzopyrones did not activate mouse macrophages.
苯并吡喃已被证明会影响巨噬细胞的多种功能。我们研究了两种苯并吡喃，香豆素和华法林，对小鼠巨噬细胞抑制微生物和肿瘤靶细胞能力的影响。给小鼠每日静脉注射任一药物。然后用致死剂量的刚地弓形虫攻击小鼠，或者用这些小鼠的腹腔巨噬细胞在体外与刚地弓形虫或肿瘤靶细胞进行挑战。用香豆素或华法林处理后再用刚地弓形虫攻击的小鼠的存活率与对照小鼠相似。在来自香豆素处理组、华法林处理组或对照组小鼠的巨噬细胞制剂中，刚地弓形虫的增殖和肿瘤靶细胞的生长相似，而在来自用微小棒状杆菌处理作为阳性对照的小鼠的活化巨噬细胞制剂中则受到抑制。在我们的实验条件下，苯并吡喃不会激活小鼠巨噬细胞。
