急性饮食限制对断奶大鼠肌纤维数量的影响。

The effect of acute dietary restriction on muscle fibre number in weanling rats.

Layman D K, Swan P B, Hegarty P V

Br J Nutr. 1981 May;45(3):475-81. doi: 10.1079/bjn19810126.

Abstract

Male Sprague-Dawley rats were allocated at 100 g into either an ad lib.-fed control group or a food-restricted group. The restricted group was fed for 9 d at 25% of ad lib. intake. Controls were killed at a body-weight of 100 g and 29 d of age. 2. The effects of food restriction on muscle weight, fibre number, fibre diameter, DNA, and protein were examined in three skeletal muscles, the soleus, plantaris and extensor digitorum longus (EDL). 3. Acute dietary restriction caused body- and muscle-weight loss and a decrease in both the number and cross-sectional area of muscle fibres in each of the muscles. 4. The restriction halted growth-related increases in DNA in all muscles and decreased the protein:DNA value in the plantaris and EDL. 5. These results indicate that present theories describing cellular development are not adequate to define growth potential or growth retardation of skeletal muscle.

摘要

将100克重的雄性斯普拉格-道利大鼠分为自由采食对照组或食物限制组。限制组按自由采食量的25%喂养9天。对照组在体重达到100克且年龄为29天时处死。2. 在比目鱼肌、跖肌和趾长伸肌（EDL）这三块骨骼肌中，研究了食物限制对肌肉重量、纤维数量、纤维直径、DNA和蛋白质的影响。3. 急性饮食限制导致体重和肌肉重量减轻，且每块肌肉中的肌纤维数量和横截面积均减少。4. 这种限制阻止了所有肌肉中与生长相关的DNA增加，并降低了跖肌和趾长伸肌中的蛋白质:DNA值。5. 这些结果表明，目前描述细胞发育的理论不足以界定骨骼肌的生长潜力或生长迟缓。