Story J A, Gomolinski E, Czarnecki S K, Tepper S A, Kritchevsky D
Lipids. 1981 Feb;16(2):87-92. doi: 10.1007/BF02535679.
Various aspects of lipid metabolism were compared in Fisher 344 (F) and Sprague-Dawley (SD) rats aged 2, 6, 12, 18 and 24 months. The analyses included free and total cholesterol of serum and liver, LCAT, hepatic HMG-CoA reductase, cholesterol 7 alpha-hydroxylase, fatty acid synthetase, acetyl CoA carboxylase and cholesterol synthesis from acetate or mevalonate. The body weight of SD rats increases with age whereas that of F rats plateaus at 9-12 months. Liver and aorta cholesterol levels were comparable for the 2 strains. Serum cholesterol varied but was usually lower in F rats. HMG-CoA reductase and cholesterol 7 alpha-hydroxylase activities were not significantly different. Cholesterol synthesis from acetate was significantly higher only in 2-month-old F rats; synthesis from mevalonate was similar at each level. Acetyl CoA carboxylase and fatty acid synthetase activity were generally higher in F rats at every age level. The major difference between F and SD rats is in their pattern of weight gain with age. Differences in lipid metabolism are most marked between the young (2-month) rats.
对2、6、12、18和24月龄的费希尔344（F）大鼠和斯普拉格-道利（SD）大鼠的脂质代谢的各个方面进行了比较。分析包括血清和肝脏中的游离胆固醇和总胆固醇、卵磷脂胆固醇酰基转移酶（LCAT）、肝脏3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶、胆固醇7α-羟化酶、脂肪酸合成酶、乙酰辅酶A羧化酶以及由乙酸盐或甲羟戊酸合成胆固醇的情况。SD大鼠的体重随年龄增加，而F大鼠的体重在9至12个月时趋于平稳。两种品系的肝脏和主动脉胆固醇水平相当。血清胆固醇有所变化，但F大鼠的血清胆固醇通常较低。HMG-CoA还原酶和胆固醇7α-羟化酶的活性没有显著差异。仅在2月龄的F大鼠中，由乙酸盐合成胆固醇的量显著更高；在各个水平上，由甲羟戊酸合成胆固醇的情况相似。在每个年龄水平，F大鼠的乙酰辅酶A羧化酶和脂肪酸合成酶活性通常更高。F大鼠和SD大鼠之间的主要差异在于它们随年龄增长的体重增加模式。脂质代谢的差异在幼年（2月龄）大鼠之间最为明显。
