Widness J A, Schwartz H C, Zeller W P, Oh W, Schwartz R
Obstet Gynecol. 1981 Apr;57(4):414-21.
As women giving birth to large for gestational age (LGA) infants are at risk for glucose intolerance during pregnancy, fasting plasma glucose (FPG) and glycohemoglobin levels (Hb AIc) were studied in the immediate postpartum period (less than 10 days). These laboratory tests, in addition to infant birth weights and perinatal histories in a group of 146 women whose infants were above the 95th percentile for gestational age, were compared with those of a group of women whose infants were appropriate for gestational age (AGA: above the 25th percentile but below the mothers 75th percentile) as well as with those of a group of control mothers without diabetic risk factors. Mean Hb AIc and FPG were elevated in the mothers of the LGA infants. When either the LGA group alone or all 3 groups together were analyzed by linear regression, significant relationships were observed for maternal Hb AIc versus FPG (P less than .001); maternal Hb AIc versus birth weight corrected for gestational age (P less than .001); and maternal FPG versus birth weight corrected for gestational age (P less than .001). In addition, infant weight correlated with maternal prepregnancy weight (r = .36), maternal weight gain in pregnancy (r = .23), and maternal height (r = .17), but not with any of the paternal anthropometric features studied. Twenty-six women with LGA infants underwent postpartum oral glucose tolerance tests before discharge. Four had abnormal results and all had Hb AIc values above SD of the nonrisk control values (5.8% total Hb). Of the 16 mothers of LGA infants with FPG levels greater than 85 mg/dl (above SD of the nonrisk control values), 7 (44%) also had Hb AIc levels of more than 5.8%. Moreover, on retrospective analysis, the LGA infants manifested increased perinatal morbidity (P less than .05) compared to the combined control groups.
由于分娩大于胎龄（LGA）婴儿的女性在孕期有发生葡萄糖耐量异常的风险，因此对产后即刻（少于10天）的空腹血糖（FPG）和糖化血红蛋白水平（Hb AIc）进行了研究。在一组146名婴儿胎龄大于第95百分位数的女性中，除了这些实验室检查结果外，还收集了婴儿出生体重和围产期病史，并将其与一组婴儿适于胎龄（AGA：大于第25百分位数但低于母亲第75百分位数）的女性以及一组无糖尿病危险因素的对照母亲进行比较。LGA婴儿母亲的平均Hb AIc和FPG升高。当单独分析LGA组或同时分析所有3组时，通过线性回归观察到母亲Hb AIc与FPG之间存在显著关系（P＜0.001）；母亲Hb AIc与校正胎龄后的出生体重之间存在显著关系（P＜0.001）；母亲FPG与校正胎龄后的出生体重之间存在显著关系（P＜0.001）。此外，婴儿体重与母亲孕前体重（r = 0.36）、孕期母亲体重增加（r = 0.23）和母亲身高（r = 0.17）相关，但与所研究的任何父亲人体测量特征均无关。26名分娩LGA婴儿的女性在出院前接受了产后口服葡萄糖耐量试验。4名结果异常，且所有患者的Hb AIc值均高于无风险对照值的标准差（总Hb为5.8%）。在16名FPG水平大于85 mg/dl（高于无风险对照值的标准差）的LGA婴儿母亲中，7名（44%）的Hb AIc水平也超过5.8%。此外，回顾性分析显示，与合并对照组相比，LGA婴儿的围产期发病率增加（P＜0.05）。
