Pharmacokinetics of 4-aminopyridine in human volunteers. A preliminary study using a new GLC method for its estimation.
作者信息
Evenhuis J, Agoston S, Salt P J, de Lange A R, Wouthuyzen W, Erdmann W
出版信息
Br J Anaesth. 1981 Jun;53(6):567-70. doi: 10.1093/bja/53.6.567.
PMID:7248119
Abstract
The concentrations of 4-aminopyridine hydrochloride in the blood and urine from volunteers were measured following a bolus injection i.v. of 0.3 mg kg-1. The drug was assayed by means of a new GLC method which is described. The pharmacokinetics of 4-aminopyridine are complicated by an additional increase in plasma concentration during the elimination phase of the drug.
摘要
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