[3H]2-氨基-6,7-二羟基-1,2,3,4-四氢萘（ADTN）：一种潜在的特异性多巴胺受体配体。

[3H] 2-Amino-6,7-dihydroxy 1,2,3,4-tetrahydronapthalene (ADTN): a potential specific dopamine receptor ligand.

作者信息

Clement-Cormier Y, Abel M

出版信息

Res Commun Chem Pathol Pharmacol. 1978 Oct;22(1):15-25.

Abstract

The characteristics of [3H] 2-amino-6,7-dihydroxy 1,2,3,4-tetrahydronapthalene (ADTN) binding to calf striatal membranes were investigated. [3H]ADTN was observed to bind with high affinity and stereospecificity to a preparation of crude synaptic membranes. A number of dopamine agonists and antagonists were studied for their ability to displace bound [3H]ADTN. Dopamine agonists were found to be more potent inhibitors of ADTN binding than were dopamine antagonists. Kinetic analysis indicates that [3H]ADTN binds to dopamine recognition sites in a manner comparable to dopamine itself. Overall, the data suggest that ADTN may be a useful ligand for the characterization of agonist requirements for recognition by dopamine binding sites.

摘要

研究了[3H] 2-氨基-6,7-二羟基-1,2,3,4-四氢萘（ADTN）与小牛纹状体膜结合的特性。观察到[3H]ADTN以高亲和力和立体特异性与粗制突触膜制剂结合。研究了多种多巴胺激动剂和拮抗剂取代结合的[3H]ADTN的能力。发现多巴胺激动剂比多巴胺拮抗剂更有效地抑制ADTN结合。动力学分析表明，[3H]ADTN以与多巴胺本身相当的方式与多巴胺识别位点结合。总体而言，数据表明ADTN可能是一种用于表征多巴胺结合位点识别激动剂需求的有用配体。

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