Dromeyer H H, Arnold W, Kryger P, Nielsen J O, Meyer zum Büschenfelde K H
Klin Wochenschr. 1981 Jun 15;59(12):675-8. doi: 10.1007/BF02593859.
In 75 healthy HBsAg carriers with normal liver tissue who were followed over a four years period, anti-HBc IgM was determined by ELISA. 61 HBsAg carriers (81%) were positive for anti-HBc IgM at first investigation. 54 individuals demonstrated persistence of anti-HBc IgM, 7 became anti-HBc IgM-negative within the observation period. 12 persons were persistent anti-HBc IgM of low quantities. 3 of 4 individuals with HBsAg clearance demonstrated a considerable decrease of anti-HBc IgM concentration. Although signs of liver damage or development of chronic liver diseases were not observed at the time of control biopsy the existence of anti-HBcIgM indicates that there exists also in healthy HBsAg carriers a persistent stimulation by HBcAg, inducing the production of anti-HBc IgM as a sign of permanent ongoing virus B replication. These results require a new and critical review of the "healthy" HBsAg carrier state.
在75名肝组织正常的健康乙肝表面抗原（HBsAg）携带者中，随访四年期间通过酶联免疫吸附测定法（ELISA）检测抗乙肝核心抗体IgM（anti-HBc IgM）。在首次检测时，61名HBsAg携带者（81%）的抗-HBc IgM呈阳性。54人抗-HBc IgM持续阳性，7人在观察期内抗-HBc IgM转阴。12人抗-HBc IgM持续低水平。4名HBsAg清除者中有3人抗-HBc IgM浓度显著下降。尽管在对照活检时未观察到肝损伤迹象或慢性肝病进展，但抗-HBc IgM的存在表明，健康HBsAg携带者中也存在乙肝核心抗原（HBcAg）的持续刺激，诱导产生抗-HBc IgM，这是乙肝病毒持续复制的标志。这些结果需要对“健康”HBsAg携带者状态进行新的批判性审视。
