Kreutz R
Anat Anz. 1981;149(2):151-9.
The present investigations was made to check the effects of repeated oral applications of the chemotherapeutic effective pirimidinsubstance trimethoprim (pure substance) at the intrauterine development in the wistar rat. The agent was given with a throat tube suspended in hydroxyacetylcellulose from the 5th to the 7th, from the 8th to the 10th and from the 11th to the 13th day p. c. The dosage was 1,500, 1,000, 750 and 200 mg trimethoprim per kg bodyweight. The valuation of the fetal development was made after the subsequent parameters: mean implantationrate, resorptionrate, mean fetal bodyweight. Statement of anomalies by inspection of the body surface shape and the brightened skeleton. The dosage of 200 mg TMP/kg bodyweight influences the fetal development only a little. Doses of 1,500, 1,000, and 750 mg TMP/kg bodyweight however show a high toxicity for the used rat strain as well for the mother animals as for the fetuses of the surviving animals. The observed increased resorption rates diminishing of the average fetal bodyweight, anomalies of the body shape and different anomalies of the skeleton are typical effects of folic acid antagonists.
本研究旨在检验化疗有效嘧啶类物质甲氧苄啶（纯物质）反复经口给药对Wistar大鼠子宫内发育的影响。在妊娠第5至7天、第8至10天和第11至13天，通过喉管将该药物悬浮于羟乙酰纤维素中给药。剂量为每千克体重1500、1000、750和200毫克甲氧苄啶。根据以下参数评估胎儿发育情况：平均着床率、吸收率、平均胎儿体重。通过检查体表形状和骨骼显影来确定有无异常。200毫克甲氧苄啶/千克体重的剂量对胎儿发育影响较小。然而，1500、1000和750毫克甲氧苄啶/千克体重的剂量对所用大鼠品系以及母鼠和存活动物的胎儿均显示出高毒性。观察到的吸收率增加、平均胎儿体重减轻、身体形状异常和骨骼不同异常是叶酸拮抗剂的典型作用。
