von Leitner E R, Kötter V, Schröder R
Dtsch Med Wochenschr. 1981 Jul 17;106(29-30):939-41.
Serious cardiac late manifestations were observed in two patients with Reiter's disease 15 and 26 years after the onset of the disease. There is a striking similarity with cardiac involvement in Bechterew's disease. Including cases reported in the literature there is an interval of 4-21 years, average 15 years, between the first conclusive symptoms of Reiter's disease and cardiac late manifestations. These present as isolated aortic valve insufficiency. Valves are not affected due to inflammatory changes but due to dilatation of the valve ring and of the left ventricular outflow channel. In addition, severe disturbances of the atrioventricular conduction are seen localised both in the AV node area and in the distal His-Purkinje fibres. In both observed cases surgical aortic valve replacement became necessary 20-31 years after disease onset. One patient had to have a permanent cardiac pacemaker.
在两名赖特综合征患者发病15年和26年后观察到严重的心脏晚期表现。这与贝赫切特病的心脏受累有显著相似之处。包括文献报道的病例在内,从赖特综合征的首个确诊症状到心脏晚期表现的间隔时间为4至21年,平均15年。这些表现为孤立性主动脉瓣关闭不全。瓣膜并非因炎症改变而受累,而是由于瓣膜环和左心室流出道扩张所致。此外,还可见严重的房室传导障碍,其定位在房室结区域和远端希氏-浦肯野纤维。在观察到的两例病例中,发病20至31年后均有必要进行外科主动脉瓣置换。其中一名患者必须植入永久性心脏起搏器。