酸性组胺溶液对豚鼠离体左肺动脉的舒张反应。
Relaxant responses of the isolated guinea-pig left pulmonary artery produced by acidic histamine solutions.
作者信息
Hand J M, Buckner C K
出版信息
Eur J Pharmacol. 1981 Mar 12;70(2):225-30. doi: 10.1016/0014-2999(81)90218-1.
Contractile responses to histamine were examined on left pulmonary arterial rings isolated from reserpine-pretreated guinea pigs. In the presence of mepyramine, contractile responses to histamine dihydrochloride and histamine diphosphate were preceded by concentration-dependent relaxant responses which were not blocked by metiamide. Hydrochloric acid also produced relaxation of the histamine- and noradrenaline-contracted vessels. Solutions of histamine dihydrochloride and histamine free base adjusted to about pH 7 did not produce the relaxant response. Changes in tissue bath pH were correlated with relaxant responses produced by acidic histamine and hydrochloric acid solutions. Relaxation produced by histamine in this preparation is due to changes in tissue bath pH and not to activation of an atypical type of histamine receptor.
对从经利血平预处理的豚鼠分离出的左肺动脉环进行了对组胺的收缩反应研究。在存在美吡拉敏的情况下，对二盐酸组胺和磷酸组胺的收缩反应之前会出现浓度依赖性的舒张反应，而该反应未被甲硫米特阻断。盐酸也能使组胺和去甲肾上腺素收缩的血管舒张。将二盐酸组胺和游离碱组胺溶液调节至约pH 7时不会产生舒张反应。组织浴pH的变化与酸性组胺和盐酸溶液产生的舒张反应相关。在此制剂中组胺产生的舒张是由于组织浴pH的变化，而非非典型组胺受体的激活。
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