Udin S B, Schneider G E
Exp Brain Res. 1981;43(3-4):261-9. doi: 10.1007/BF00238367.
After partial ablation of the superior colliculus (tectum) in neonatal hamsters, the whole extent of the visual field comes to be represented in a compressed map on the remaining tectal fragment. However, the total volume of tectal tissue in which retinotectal fibers arborize is less than normal. These observations suggests that the retinal ganglion cells which arborize in this reduced volume might arise throughout the whole extent of the retina but be fewer in number than normal. Alternatively, the ganglion cells which project to the tectum might be normal in number but reduced in terminal arbor size. To distinguish between these possibilities, we have used tectal injections of horseradish peroxidase to label retinal ganglion cells which project to the tectum. The numbers of labelled cells per mm2 of retina were counted in selected regions. In hamsters with small lesions, which left 80--85% of the tectum intact, the density of labelled retinal ganglion cells was normal. However, in hamsters with larger lesions, the density of labelled cells was significantly lower than normal.
新生仓鼠上丘（顶盖）部分切除后，整个视野会在剩余顶盖碎片上以压缩图的形式呈现。然而，视网膜顶盖纤维分支所在的顶盖组织总体积小于正常水平。这些观察结果表明，在这一减小的体积内分支的视网膜神经节细胞可能起源于整个视网膜范围，但数量比正常情况少。或者，投射到顶盖的神经节细胞数量可能正常，但终末分支大小减小。为了区分这些可能性，我们通过向顶盖注射辣根过氧化物酶来标记投射到顶盖的视网膜神经节细胞。在选定区域计数每平方毫米视网膜上标记细胞的数量。在小损伤的仓鼠中，顶盖保留80 - 85%，标记的视网膜神经节细胞密度正常。然而，在损伤较大的仓鼠中，标记细胞的密度显著低于正常水平。
