Kaiser H, Gründler U, Schrader J, Blanke H, Rentrop P, Kreuzer H
Z Kardiol. 1981 Jul;70(7):536-9.
40 patients with acute myocardial infarction had serial determinations of CK, CKMB and an addition of serum myoglobin (SMb) by radioimmunoassay. In 10 patients with normal values on admission SMb rose earlier than CK and CKMB. In another 20 patients SMb was pathologically increased while CK and CKMB were normal and in 10 patients all parameters were elevated on admission. In all 40 patients SMb was significantly elevated in between 10 hrs after beginning of angina, and peak myoglobin occurred 10 hrs before CK and CKMB. In 10 patients peak SMb correlated with infarct size as determined by angiocardiography in the chronic stage (r = 0.863; p less than 0.01). Peak SMb also correlated with infarct size as estimated by CK release (r = 0.73; p less than 0.001). Thus determination of SMb is a sensitive method in diagnosing early myocardial infarction, and peak serum myoglobin allows early prediction of infarct size.
40例急性心肌梗死患者接受了肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）的系列测定，并通过放射免疫测定法额外检测了血清肌红蛋白（SMb）。10例入院时各项指标正常的患者，其SMb升高早于CK和CK-MB。另外20例患者SMb呈病理性升高，而CK和CK-MB正常；10例患者入院时所有参数均升高。在全部40例患者中，心绞痛发作开始后10小时内SMb显著升高，肌红蛋白峰值出现在CK和CK-MB之前10小时。10例患者的SMb峰值与慢性期心血管造影确定的梗死面积相关（r = 0.863；p < 0.01）。SMb峰值也与根据CK释放量估算的梗死面积相关（r = 0.73；p < 0.001）。因此，测定SMb是诊断早期心肌梗死的一种敏感方法，血清肌红蛋白峰值可用于早期预测梗死面积。
