Tsuyumu M, Reulen H J, Prioleau G
Acta Neurochir (Wien). 1981;57(1-2):1-13. doi: 10.1007/BF01665107.
Previous studies showed that resolution of brain oedema may occur by clearance into the CSF. The present study was performed to measure quantitatively the amount of oedema clearance in cold-induced oedema in cats. In order to determine the minute amounts of oedema fluid entering the CSF the oedema fluid was labelled with a high concentration of an extracellular marker (S35-sodium-thiosulphate). Ventriculo-cisternal perfusion was used to collect the marker in the cisternal outflow. By using the assumption that oedema fluid has the same marker concentration as the plasma, the distribution profile of extracellular space as well as the clearance rate of oedema into CSF could be computed. Oedema and thiosulphate space were most pronounced in the white matter underlying the cortical cold injury. The values then declined progressively with the distance from the lesion towards the ventricle. Oedema fluid clearance into the ventricular CSF at 24 hours following the cold injury amounted to 0.8-1.2 microliter/min or 1.15 ml/day. These data support the assumption that this may be one of the main mechanisms of the resolution of vasogenic brain oedema.
先前的研究表明，脑内水肿可能通过清除进入脑脊液而消退。本研究旨在定量测量猫冷诱导性水肿中水肿清除的量。为了确定进入脑脊液的微量水肿液，用高浓度的细胞外标记物（S35-硫代硫酸钠）标记水肿液。采用脑室-脑池灌注法收集脑池流出液中的标记物。假设水肿液与血浆具有相同的标记物浓度，就可以计算细胞外间隙的分布情况以及水肿进入脑脊液的清除率。水肿和硫代硫酸盐间隙在皮质冷损伤下方的白质中最为明显。然后，这些值随着离病变部位向脑室的距离增加而逐渐下降。冷损伤后24小时，进入脑室脑脊液的水肿液清除量为0.8 - 1.2微升/分钟或1.15毫升/天。这些数据支持这样一种假设，即这可能是血管源性脑水肿消退的主要机制之一。
