Batrak G E, Khrustalev S I, Makarenko A N
Farmakol Toksikol. 1981 Jul-Aug;44(4):395-400.
Acute experiments have shown that as ftorotan anesthesia is enhanced, the supraoptical nucleus of the hypothalamic area deprived of the effect of the orbitofrontal zone of the cerebral cortex gets less resistant to ftorotan than the analogous nucleus experiencing the influence of the cortical zones. The greatest resistance to ftorotan anesthesia was displayed by the orbitofrontal zone of the cortex. In the course of the animals' egress from anesthesia, the bioelectrical activity got recovered in the following way: first in the orbitofrontal zone of the cortex, then in the supraoptical nuclei of the hypothalamic area that retained the influence of the cortex, and, finally, in the supraoptic nuclei deprived of the subordination effect of the cortex.
急性实验表明,随着氟托罗坦麻醉作用增强,下丘脑区域的视上核在失去大脑皮质眶额区影响时,相较于受皮质区域影响的类似核团,对氟托罗坦的耐受性更低。皮质眶额区对氟托罗坦麻醉的耐受性最强。在动物从麻醉中苏醒的过程中,生物电活动按以下方式恢复:首先在皮质眶额区恢复,然后在保留皮质影响的下丘脑区域视上核恢复,最后在失去皮质支配作用的视上核恢复。