Hammad D, Omar S A, Varma S
Indian J Physiol Pharmacol. 1981 Apr-Jun;25(2):123-30.
The cardiac effects of magnesium were studied on 40 spontaneously beating rabbit atria at 37 degrees C. Magnesium administered in doses of 30, 60, 120 and 240 mmol elicited dose dependent negative inotropic and chronotropic responses. Larger doses above 240 mmol caused complete atrial arrest. Further it was observed that propranolol with magnesium became more effective in blocking the positive chronotropic and inotropic responses to isoprenaline. The finding is interesting and suggestive that magnesium could be employed either alone or in combination with propranolol in treatment of arrhythmias which are non-responsive to propranolol.
在37摄氏度下，对40个自发搏动的兔心房研究了镁的心脏效应。以30、60、120和240毫摩尔的剂量给予镁，引发剂量依赖性的负性肌力和变时反应。高于240毫摩尔的更大剂量导致完全性心房停搏。此外，观察到普萘洛尔与镁联合使用在阻断对异丙肾上腺素的正性变时和变力反应方面更有效。这一发现很有趣且具有提示意义，即镁可单独使用或与普萘洛尔联合用于治疗对普萘洛尔无反应的心律失常。
