西咪替丁未能抑制原发性甲状旁腺功能亢进症患者的免疫反应性甲状旁腺激素及高钙血症。
Failure of cimetidine to suppress immunoreactive parathyroid hormone and hypercalcaemia in primary hyperparathyroidism.
作者信息
Mallett R B, Sainsbury R, Benton K G
出版信息
Postgrad Med J. 1981 Apr;57(666):242-3. doi: 10.1136/pgmj.57.666.242.
Abstract
Cimetidine has been reported as suppressing the excess parathyroid hormone secretion and hypercalcaemia seen in hyperparathyroidism. A case of primary hyperparathyroidism is described, in which the level of circulating parathyroid hormone and hypercalcaemia remain entirely unaffected by cimetidine. The drug is implicated in the management of primary hyperparathyroidism unsuitable for surgery, but present evidence, as reviewed, is insufficient to recommend the use of cimetidine in this way.
摘要
据报道，西咪替丁可抑制甲状旁腺功能亢进症中出现的甲状旁腺激素分泌过多和高钙血症。本文描述了一例原发性甲状旁腺功能亢进症病例，其中循环甲状旁腺激素水平和高钙血症完全不受西咪替丁影响。该药物被认为可用于治疗不适于手术的原发性甲状旁腺功能亢进症，但经审查，目前的证据不足以推荐以这种方式使用西咪替丁。
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本文引用的文献
1
Cimetidine in hyperparathyroidism.
Lancet. 1980 May 3;1(8175):980-1.
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Effect of cimetidine on circulating parathyroid hormone in primary hyperparathyroidism.
Lancet. 1980 Mar 22;1(8169):616-20. doi: 10.1016/s0140-6736(80)91117-4.
3
Hyperparathyroidism--a reversible cause of cimetidine-resistant gastric hypersecretion.
Br Med J. 1979 Jun 30;1(6180):1765-6. doi: 10.1136/bmj.1.6180.1765.
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