Fager G, Wiklund O, Olofsson S O, Wilhelmsen L, Bondjers G
Arteriosclerosis. 1981 Jul-Aug;1(4):273-9. doi: 10.1161/01.atv.1.4.273.
In 25 middle-aged infarction survivors and 76 corresponding controls, representative for a well-defined community, multivariate analysis was used to evaluate whether serum apolipoproteins were better discriminators of infarction survivors than serum lipids and other risk factors. Levels of serum cholesterol and triglycerides, alphalipoprotein cholesterol, apolipoproteins A-I, A-II, B, and D, as well as tobacco smoking and other risk factors, were included. In descending order, serum apo A-II levels (t(b) = -3.12, p = 0.002), tobacco consumption (t(b) = 2.64, p = 0.010), and serum triglycerides (t(b) = 2.06, p = 0.042) contributed significantly to the multiple regression on myocardial infarction (R = 0.53, p = 0.00001). When entered into ka discriminant function, these three variables gave a good separation between survivors and controls. Of the survivors, 50% were above the 90th percentile inthe control group. The relative prevalence of infarction increased continuously with increasing values of the function from zero to more than 6 times the average. Serum apo A-II levels alone were almost as good in separating cases and controls. From this study, we concluded that, among apolipoproteins, apo A-II seems to be a more sensitive discriminator of infarction survivors than other risk factors.
在25名中年心肌梗死幸存者和76名相应对照者（代表一个明确界定的社区）中，采用多变量分析来评估血清载脂蛋白是否比血清脂质和其他危险因素更能区分心肌梗死幸存者。纳入了血清胆固醇和甘油三酯水平、α脂蛋白胆固醇、载脂蛋白A-I、A-II、B和D，以及吸烟和其他危险因素。按降序排列，血清载脂蛋白A-II水平（t(b)=-3.12，p=0.002）、烟草消耗量（t(b)=2.64，p=0.010）和血清甘油三酯（t(b)=2.06，p=0.042）对心肌梗死的多元回归有显著贡献（R=0.53，p=0.00001）。当纳入判别函数时，这三个变量能很好地区分幸存者和对照者。在幸存者中，50%高于对照组的第90百分位数。梗死的相对患病率随着函数值从零增加到平均水平的6倍以上而持续上升。仅血清载脂蛋白A-II水平在区分病例和对照方面几乎同样有效。从这项研究中，我们得出结论，在载脂蛋白中，载脂蛋白A-II似乎比其他危险因素更能敏感地区分心肌梗死幸存者。
