Carr B I, Laishes B A
Br J Cancer. 1981 Oct;44(4):567-71. doi: 10.1038/bjc.1981.227.
Resistance to the cytocidal action of Adriamycin (ADR) was induced in rat hepatocytes by incorporation of the carcinogen 2-acetylaminofluorene (AAF) into the rat diet. Using a quantitative assay in primary monolayer culture, it was demonstrated that resistance to ADR is an early phenotypic change that is induced during chemical carcinogenesis in the rat, and appears to be stable.
通过在大鼠饮食中加入致癌物2-乙酰氨基芴(AAF),在大鼠肝细胞中诱导出对阿霉素(ADR)细胞杀伤作用的抗性。利用原代单层培养中的定量测定法,证明对ADR的抗性是大鼠化学致癌过程中诱导的一种早期表型变化,并且似乎是稳定的。