Bibby M C, Double J A, Mughal M A
Br J Cancer. 1981 Oct;44(4):572-7. doi: 10.1038/bjc.1981.228.
Pre-treatment with the anabolic steroid nandrolone decanoate (ND) increases the LD50 of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 5-Fluorouracil (FU) in NMRI mice. Administration of ND did not affect the anti-tumour action of CCNU against a transplantable mouse adenocarcinoma of the colon (MAC 13) or the anti-tumour action of FU against MAC 26. In both tumour lines ND had no significant effect on tumour growth. These data suggest that an increase in the anti-tumour selectivity of these agents may be produced by pre-treatment with ND.
用合成代谢类固醇癸酸诺龙(ND)进行预处理可提高NMRI小鼠对1-(2-氯乙基)-3-环己基-1-亚硝基脲(CCNU)和5-氟尿嘧啶(FU)的半数致死量(LD50)。给予ND并不影响CCNU对可移植性小鼠结肠腺癌(MAC 13)的抗肿瘤作用,也不影响FU对MAC 26的抗肿瘤作用。在这两种肿瘤模型中,ND对肿瘤生长均无显著影响。这些数据表明,用ND预处理可能会提高这些药物的抗肿瘤选择性。