[肝脏缺血时内质网膜中脂质过氧化及混合功能氧化酶系统损伤]

[Lipid peroxidation and damage to the mixed function oxidase system in membranes of the endoplasmic reticulum in the presence of liver ischemia].

作者信息

Velikhanova D M, Bilenko M V, Kagan V E

出版信息

Biull Eksp Biol Med. 1981 Jul;92(7):50-2.

Abstract

The content of endogenous lipid peroxidation products and variations in mixed function oxygenases were examined in liver microsomes of rats exposed to thermal ischemia of varying duration (15, 30, 60 and 120 min). The development of ischemic injury was accompanied by the accumulation of lipid hydroperoxides and Schiff's base, by the lowering of the content of cytochrome P-450 and diminution of the activity of NADPH-cytochrome P-450 reductase. The maximum changes were demonstrated 2 hours after ischemia. The presence of a reverse correlation between the content of lipid peroxidation products and the content of cytochrome P-450 was recorded.

摘要

检测了暴露于不同时长（15、30、60和120分钟）热缺血的大鼠肝微粒体中内源性脂质过氧化产物的含量以及混合功能氧化酶的变化。缺血性损伤的发展伴随着脂质氢过氧化物和席夫碱的积累，细胞色素P-450含量的降低以及NADPH-细胞色素P-450还原酶活性的减弱。缺血后2小时出现最大变化。记录到脂质过氧化产物含量与细胞色素P-450含量之间存在负相关。

相似文献

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