一些新合成的曼尼希碱的神经药理学作用。
Neuropharmacological actions of some newly synthesized Mannich bases.
作者信息
Tongia S K, Trivedi C P, Matkar S V, Chouhan R S, Kaushal R
出版信息
Indian J Physiol Pharmacol. 1981 Jul-Sep;25(3):269-73.
PMID:7298153
Abstract
Benzamido (alkyl) methyl pyrrolidine Mannich bases were synthetized and subjected to certain neuropharmacological studies. All the bases reduced the pentobarbitone sleeping time and rota-rod grip of rats. The Mannich bases II, III and V raised the minimal electro-shock seizure threshold of rats. The TAB-induced pyrexia was not reduced by the bases I and III in rabbits. None of the bases showed any significant analgesic activity.
摘要
合成了苯甲酰胺基（烷基）甲基吡咯烷曼尼希碱并进行了某些神经药理学研究。所有这些碱都缩短了大鼠的戊巴比妥睡眠时间并降低了大鼠的转棒抓握能力。曼尼希碱II、III和V提高了大鼠的最小电击惊厥阈值。碱I和III对家兔的TAB诱导发热没有降温作用。这些碱均未表现出任何显著的镇痛活性。
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