Steinhagen-Thiessen E, Reznick A Z, Hilz H
Mech Ageing Dev. 1981;16(4):363-9. doi: 10.1016/0047-6374(81)90020-8.
CWI mice at the age of 6, 22 and 27 months were subjected to a controlled physical training program for 5 weeks. Changes in specific activity of the enzymes aldolase, superoxide dismutase and catalase of the total hind-leg muscle tissues were followed. During the training period, specific activities of these muscle enzymes exhibited an adaptive increase in the 6 and 22 months groups. In senile (27 months) mice, however, enzyme activities decreased as a consequence of the physical challenge. Total body weight was not altered under these conditions. Immunotitration of extracts with anti-aldolase and anti-creatine kinase antibodies showed no significant differences, indicating that there was no accumulation of disappearance of faulty proteins during aging and physical exercise.
对6个月、22个月和27个月大的CWI小鼠进行了为期5周的受控体育训练计划。跟踪了后肢肌肉组织中醛缩酶、超氧化物歧化酶和过氧化氢酶的比活性变化。在训练期间，这些肌肉酶的比活性在6个月和22个月大的组中呈现适应性增加。然而，在老年（27个月）小鼠中，酶活性因体育锻炼而降低。在这些条件下，总体重没有改变。用抗醛缩酶和抗肌酸激酶抗体对提取物进行免疫滴定没有显示出显著差异，表明在衰老和体育锻炼过程中没有错误蛋白质的积累或消失。
