Rockstein M, Lopez T, Chesky J A
Mech Ageing Dev. 1981;16(4):379-83. doi: 10.1016/0047-6374(81)90022-1.
Male Fischer 344 rats from a long inbred colony (by brother-sister mating) were subjected to moderate (forced swimming) physical activity on a regular basis, beginning at 3 weeks following weaning. Normally caged, sedentary littermates were employed as controls at each age level. Exercised animals showed a greater total ventricular mass and correspondingly lower body weight, and the heart to body weight ratio for experimental animals about 25% higher at all ages, beginning at 3 months following onset of exercise. Finally, the specific activity of myocardial creatine phosphokinase was consistently higher for the exercised animals, beginning at 3 months of age and through 16 months of such exercise. These data support previous findings from this laboratory, as well as by others, that long-term moderate exercise begun early in life has a continuing, beneficial effect on the mammalian heart, both at the gross functional and intracellular biochemical levels.
来自长期近亲繁殖群体（通过兄妹交配）的雄性费希尔344大鼠，从断奶后3周开始定期进行适度（强迫游泳）体育活动。正常笼养、久坐不动的同窝大鼠在每个年龄水平用作对照。运动的动物表现出更大的心室总质量，相应地体重更低，并且从运动开始3个月起，实验动物的心脏与体重比在所有年龄段均高出约25%。最后，从3月龄开始并持续进行16个月这种运动后，运动动物的心肌肌酸磷酸激酶的比活性始终更高。这些数据支持了本实验室以及其他实验室先前的研究结果，即生命早期开始的长期适度运动在总体功能和细胞内生化水平上对哺乳动物心脏都有持续的有益影响。
