Perez G O, Epstein M, Rietberg B, Horton C
Ren Physiol. 1981;4(4):157-64. doi: 10.1159/000172822.
To date, the renal handling of amino acids by remnant kidneys remains undefined. We have determined the renal handling of eight amino acids using the isolated perfused rat kidney. 6 normal and 22 partially infarcted rat kidneys (16 stage III [contralateral kidney removed], and 6 stage II [contralateral kidney left intact] were evaluated at perfusate amino acid concentrations approximately ten times normal plasma levels. Despite the reduction in glomerular filtration rate, the urinary excretion of most amino acids in remnant kidneys tended to exceed that of controls. Fractional amino acid excretion by both stage II and III kidneys tended to be or was higher than that of controls. The findings indicate that the fractional reabsorption of amino acids by residual nephrons of remnant kidneys is decreased. Our observations suggest that the changes are unrelated to a functional adaptation to the uremic environment.
迄今为止，残余肾对氨基酸的肾脏处理情况仍不明确。我们使用离体灌注大鼠肾脏确定了八种氨基酸的肾脏处理情况。在灌注液氨基酸浓度约为正常血浆水平十倍的情况下，对6个正常大鼠肾脏和22个部分梗死的大鼠肾脏（16个III期[对侧肾切除]和6个II期[对侧肾完整]）进行了评估。尽管肾小球滤过率降低，但残余肾中大多数氨基酸的尿排泄量往往超过对照组。II期和III期肾脏的氨基酸排泄分数往往或高于对照组。这些发现表明，残余肾残余肾单位对氨基酸的重吸收分数降低。我们的观察结果表明，这些变化与对尿毒症环境的功能适应无关。
