[Endothelial culture on fibrillar collagen: a model for studying the directed transport of liposomes to the collagen matrix].

A directed transport of liposomes to fibrillar collagen was studied using the model system in which a partial reconstruction was made of the normal, locally injured, and vastly injured vascular wall from the endothelial cell culture grown on fibrillar collagen. The binding of fibrillar collagen with conjugates liposome--anticollagen antibody and liposome-fibronectin is 3.5--4 times higher, than conjugates liposome nonspecific IgG and liposomes. The binding of conjugates liposomes--anticollagen antibody and liposome--fibronectin with the surface of endothelial cell is 7--8 times lower than with the surface of fibrillar collagen.