补充必需氨基酸对慢性尿毒症患者肌肉及血浆游离氨基酸的影响。

Effect of essential amino acid supplementation on muscle and plasma free amino acids in chronic uremia.

作者信息

Alvestrand A, Bergström J, Fürst P, Germanis G, Widstam U

出版信息

Kidney Int. 1978 Oct;14(4):323-9. doi: 10.1038/ki.1978.131.

DOI:10.1038/ki.1978.131

PMID:732092

Abstract

In chronic uremia patients on an 18-g protein diet for 2 to 3 weeks, the intracellular free amino acid pattern in muscle was grossly abnormal, with low concentrations of threonine, valine, carnosine, and high concentrations of aspartate, glutamine, glycine, alanine, and taurine. When the protein-poor diet was supplemented with essential amino acids (2 to 3 times that for minimum requirements) and histidine, these abnormalities were partly corrected. Other abnormalities, however, were observed, such as low intracellular concentrations of phenylalanine and tyrosine, and high concentrations of lysine, histidine, ornithine, and citrulline.

摘要

在接受18克蛋白质饮食2至3周的慢性尿毒症患者中，肌肉细胞内游离氨基酸模式严重异常，苏氨酸、缬氨酸、肌肽浓度较低，而天冬氨酸、谷氨酰胺、甘氨酸、丙氨酸和牛磺酸浓度较高。当低蛋白饮食补充必需氨基酸（为最低需求量的2至3倍）和组氨酸时，这些异常情况得到部分纠正。然而，还观察到其他异常情况，如细胞内苯丙氨酸和酪氨酸浓度较低，以及赖氨酸、组氨酸、鸟氨酸和瓜氨酸浓度较高。