Hayashi I, Okamoto H
Jpn J Antibiot. 1981 Jul;34(7):1098-105.
Dibekacin was used for the treatment of 5 patients with bacterial respiratory tract infections (4 cases of Ps. aeruginosa and 1 case of S. marcescens) intravenously. Serum levels of DKB was observed by the method of enzyme immunoassay (EIA) and bioassay and no differentiation was observed between EIA and bioassay. Four cases of Ps. aeruginosa and 1 case of S. marcescens were all disappeared in 5 or 7 days of administration. No side effects were observed. The results obtained in this study indicate that DKB intravenous challenge might become one of the important method on respiratory tract infections.
地贝卡星用于5例细菌性呼吸道感染患者(4例铜绿假单胞菌感染和1例粘质沙雷氏菌感染)的静脉治疗。采用酶免疫测定法(EIA)和生物测定法观察地贝卡星的血清水平,未观察到EIA和生物测定法之间的差异。4例铜绿假单胞菌感染患者和1例粘质沙雷氏菌感染患者在给药5或7天后全部痊愈。未观察到副作用。本研究结果表明,静脉注射地贝卡星可能成为治疗呼吸道感染的重要方法之一。