Ebbesen F, Brodersen R
Acta Paediatr Scand. 1981 Sep;70(5):649-53. doi: 10.1111/j.1651-2227.1981.tb05762.x.
Fifty-nine jaundiced light treated newborn infants with low birth weight were studied. At onset of phototherapy 30 infants received 1 g human serum albumin per kg body weight as a 9% solution containing sodium caprylate and N-acetyltryptophan as stabilizers. 29 infants did not receive human serum albumin and served as controls. Blood samples were taken before initiation of the therapy and again 24 and 48 h thereafter, and the following determinations were made: Serum concentrations of unconjugated bilirubin, albumin, reserve albumin for binding of bilirubin by the [14C]-MADDS method, packed cell volume and pH. Before infusion of albumin it was found that the binding fraction of serum albumin, i.e. the sum of the serum concentrations of bilirubin-albumin and reserve albumin, constituted about half of the total serum albumin concentration. The other half was non-binding, in agreement with previous findings in neonates. The effect of albumin therapy was mainly an unexpected increase of the non-binding fraction of serum albumin, while the increase of the serum reserve albumin concentration was small and the concentration of bilirubin-albumin was not changed.
对59名低体重黄疸光疗新生儿进行了研究。在光疗开始时，30名婴儿每公斤体重接受1克人血清白蛋白，制成含辛酸钠和N - 乙酰色氨酸作为稳定剂的9%溶液。29名婴儿未接受人血清白蛋白，作为对照。在治疗开始前、治疗后24小时和48小时再次采集血样，并进行以下测定：血清未结合胆红素、白蛋白、通过[14C]-MADDS法测定的胆红素结合储备白蛋白、红细胞压积和pH值。在输注白蛋白之前，发现血清白蛋白的结合部分，即胆红素 - 白蛋白和储备白蛋白的血清浓度之和，约占血清总白蛋白浓度的一半。另一半是非结合性的，这与之前在新生儿中的发现一致。白蛋白治疗的效果主要是血清白蛋白非结合部分意外增加，而血清储备白蛋白浓度增加较小，胆红素 - 白蛋白浓度未改变。
